2018 Meeting Schedule
6:30AM to 7AM Breakfast: Grand Promenade
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7:00 to 9:00 AM: Grand Ballroom 3 and 4 iPSC-based platform development for major psychiatric disorder modeling and discovery: Chair, Guang Chen, Janssen R&D LLC., Johnson and Johnson; Co-chair, Sue O’Shea, University of Michigan “Using patient-derived neural cells to study Bipolar Disorder – Carol Marchetto, Salk Institute” Role of CACNA1C—a shared risk factor in neuropsychiatric disorders – Katarzyna Glanowska, University of Michigan Role of a psychiatric disease risk factor in synaptic function and gene transcription regulation – Kimberly Christian, University of Pennsylvania Perelman School of Medicine Phenotypic screening of hiPSC derived neurons: Balancing throughput with relevance – Anne Bang, Sanford Burnham Prebys Medical Discovery Institute |
7:00 to 9:00 AM: Grand Ballroom 5 The new kid on the block: glia in mental and cognitive disorders: Chair: Misha Pletnikov, Johns Hopkins University School of Medicine; Co-chair: Robert McCullumsmith, University of Cincinnati Bioenergetic defects in severe mental illness: An intermediate phenotype that links genomic risk with psychopathology? – Robert McCullumsmith, University of Cincinnati Genetic risk factors in neuron-astrocyte energy coupling and cognitive dysfunction – Mikhail Pletnikov, Johns Hopkins University School of Medicine Contribution of glia and extracellular matrix interactions to the pathophysiology of schizophrenia and bipolar disorder – Harry Pantazopoulos, Harvard Medical School Experience-dependent plasticity of astrocytes – Kathryn Reissner, University of North Caroline at Chapel Hill |
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9:15 to 11:15 AM: Grand Ballroom 3 and 4 Diseases of the social brain: Chair, Gul Dolen, Johns Hopkins; Co-chair, Andreas Meyer Lindenberg, Central Institute of Mental Health Neural mechanisms of social risk for schizophrenia – Andreas Meyer-Lindenberg, Central Institute of Mental Health Mannheim Evidence Base for Phase 3 Trials of MDMA-assisted Psychotherapy, a Breakthrough-Designated Treatment for PTSD – Berra Yazar-Klosinski, Multidisciplinary Association for Psychedelic Studies Probing social motivation in autism – Barbara Thompson, University of Southern California Social reward learning: basic mechanisms and therapeutic opportunities – Gul Dolen, Johns Hopkins |
9:15 to 11:15 AM: Grand Ballroom 5 Calcium Mechanisms in Bipolar Disorder: A review of genetic evidence and cellular models: Chair, John Nurnberger, Indiana University School of Medicine; Co-chair, John Kelsoe, UCSD Introduction – John Kelsoe, UCSD Genetic data and gene expression data supporting calcium involvement in bipolar disorder – Ney Alliey-Rodriguez, University of Chicago Characterizing rare variants that influence risk for bipolar disorder – Seth Ament, University of Maryland School of Medicine L-type voltage-gated calcium channels: complex proteins; complex phenotypes – Geoff Murphy, University of Michigan Mechanisms underlying hyperexcitability in hippocampal neurons derived from bipolar disorder patients in experiment and computational modeling – Shani Stern, Salk Institute |
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11:30 AM to 1:30 PM: Grand Ballroom 3 and 4 Utilizing diversity of model organisms for studying the molecular basis of neuropsychiatric disorders: Chair, Michael Yartsev, UC Berkley; Co-chair, Daniel Kronauer, Rockefeller University Towards treating psychiatric disease with holographic optogenetics – Hillel Adesnik, University of Berkeley Neural circuit mechanisms of valence processing – Kay Tye, MIT Fronto-striatal control of anxiety-like behavior – Lisa Gunaydin, UCSF Neurobiological mechanisms of vocal production learning of social calls – Michael Yartsev, UC Berkley |
11:30 AM to 1:30 PM: Grand Ballroom 5 ISN Symposium: Molecular insights on organoid and 3D models to study brain diseases and development: Chair, Orly Reiner, Weizmann Institute of Science; Co-chair, Jeremy Crook, University of Wollongong Using human brain organoids to model ASD and schizophrenia – Mandy Johnstone, University of Edinburgh Modeling of major mental disorders using tissue engineering approaches – Jeremy Crook, University of Wollongong Live-imaging of human brain organoids for disease modeling – Orly Reiner, Weizmann Institute of Science Long term maturation of human cortical forebrain spheroids models post-natal brain development – Aaron Gordon, UCLA |
1:30 to 7:00 PM Break
7:00 to 8:00 PM: Grand Ballroom 3 and 4
Plenary talk: Rick Huganir “Regulation of Neurotransmitter Receptors in Cognition and Cognitive Disorders”, Introduction by Rob Malenka, Stanford
6:30AM to 7AM Breakfast: Grand Promenade
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7:00 to 9:00 AM: Grand Ballroom 3 and 4 Building on advances in genetics to validate novel molecular targets for treatment of schizophrenia: Chair, Jeff Conn, Vanderbilt University; Co-chair, Amy Arnsten, Yale University Patient-derived de novo variation of CACNA1I impairs sleep spindles in mice: implication for novel therapeutic strategies – Jen Pan, Stanley Center for Psychiatric Research AS3MT and Schizophrenia – From GWAS Locus to Chemical Biology Tools – James Barrow, Lieber Institute The Druggable Genome: Key Actions of mGluR3 in the Prefrontal Cortical Circuits Most Impacted in Schizophrenia – Amy Arnsten, Yale University Genetic Insights Lead to Discovery of Selective Activators of mGlu1 and mGlu3 Metabotropic Glutamate Receptors as Potential Treatments for Schizophrenia – Jeff Conn, Vanderbilt University |
7:00 to 9:00 AM: Grand Ballroom 5 The Neural Circuitry underlying Social Dysfunction – Chair, Byungkook Lim, UCSD; Co-chair, Weizhe Hong, UCLA Dysfunction of reward circuits as a consequence of chronic stress – Scott Thompson, University of Maryland The neural basis of early-life stress induced social dysfunction – Byoungkook Lim, UCSD Neural circuitry for the innate social behaviors – Weizhe Hong, UCLA Elucidating neural circuits underlying autism-like behaviors – Gloria Choi, MIT |
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9:15 to 11:15 AM: Grand Ballroom 3 and 4 Somatic mosaicism in the brain: Diverse Neuronal Genomes and Neuropsychiatric Disorders: Chair, Alexander Urban, Stanford University; Co-chair, Douglas Ruderfer, Vanderbilt University Machine learning analysis of ultra-deep whole-genome sequencing in human brain reveals somatic retrotransposition in both neurons and glia – Alexander Urban, Stanford University A functional role of somatic retrotransposition in schizophrenia associated sensorimotor gating deficit – Anindita Sarkar, Salk Institute Somatic SNVs in brain during aging and in degenerative disorders – Michael Coulter, Harvard Medical School Human neural progenitor cells harbor DNA double-strand breaks in genes linked to autism – Meiyan Wang, Salk Institute |
9:15 to 11:15 AM: Grand Ballroom 5 Cortico-striatal circuits in addiction and compulsion: Chair, Mark Thomas, University of Minnesota; Co-chair, Michael Bruchas, University of Washington Interruption of Continuous Opioid Exposure Exacerbates Drug-Evoked Adaptations in the Nucleus Accumbens – Patrick Rothwell, University of Minnesota Dissecting nucleus accumbens circuits in reward seeking – Michael Bruchas, University of Washington Individual differences in repetitive behavior associate with striatal neuron subtype transcriptomes – Mary Kay Lobo, University of Maryland Fronto-striatal connections in decision making and addiction – Mark Thomas, University of Minnesota |
11:30 AM to 1:00 PM: Grand Ballroom 3 and 4
Poster Talks, Chair, Tracey Petryshen, Massachusetts General Hospital and Concert Pharmaceuticals
11:30-11:40am: Corticostriatal circuit defects in Hoxb8 mouse model of repetitivebehaviors – Naveen Nagarajan, University of Utah
11:40-11:50am: Novel diurnal patterns of gene expression in the schizophrenic brain – Colleen McClung, University of Pittsburgh
11:50am-12:00pm: A human stem cell resource for modeling genetic variation – Ralda Nehme, Broad Institute
12:00-12:10pm: Phenotypic landscape of schizophrenia-associated genes defines candidates and their shared functions – Summer Thyme, Harvard University
12:10-12:20pm: Altered connectivity in Rett syndrome stem cell-derived cortical neural networks – Rebecca Mok, University of Toronto
12:20-12:30pm: Molecular Insults to Higher-Order Dorsolateral Prefrontal Cortical Circuits: Implications for the Pathogenesis of Schizophrenia – Dibyadeep Datta, Yale University
12:30-12:40pm: Hyper-excitable neurons produce hypo-functional neuronal networks: Evidence from modeling bipolar disorder with mouse models and hiPSCs – Cameron Pernia, Sanford Burnham Prebys Medical Discovery Institute
12:40-12:50pm: Single-cell transcriptome analysis of embryonic mouse cortex reveals developmental trajectories of ASD risk gene expression – Kristina Yim, Yale School of Medicine
12:50-1:100: Identification of spatiotemporally resolved GPCR protein interaction networks regulating receptor function – Ruth Huttenhain, UCSF
1:00 to 6:00 PM Break
6:00 to 8:00 PM: Grand Promenade
Poster Session and Reception – Hosted by Concert Pharmaceuticals
6:30AM to 7AM Breakfast: Grand Promenade
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7:00 to 9:00 AM: Grand Ballroom 3 and 4 Molecular mechanisms of Autism Spectrum Disorders: Chair, Brady Maher, Lieber Institute; Co-chair: Brian Luikart, Geisel School of Medicine at Dartmouth A genomics based approach to the etiology of autism – Tychele Turner, University of Washington Gene, Brain, and Behavior: interrogating the fundamentals of neurodevelopmental disorders – Xinyu Zhao, University of Wisconsin-Madison SCN2A in autism spectrum disorder – Kevin Bender, UCSF Post-Synaptic Neurons of a Mouse Model for Autism Display a Competitive Advantage in Recruiting Pre-Synaptic Inputs – Brian Luikart, Geisel School of Medicine at Dartmouth Multi-model system approach to functionalizing ASD variants – Kurt Haas, University of British Columbia |
7:00 to 9:00 AM: Grand Ballroom 5 Central and peripheral actions of insulin: Implications for psychiatric disorders: Chair, Michael McCarthy, UCSD; Co-chair, Zachary Freyberg, University of Pittsburgh Antipsychotics: Effects on brain insulin action in relation to whole body metabolism – Margaret Hahn, University of Toronto Novel roles for pancreatic dopamine signaling in metabolic regulation and antipsychotic drug action – Zachary Freyberg, University of Pittsburgh Dopamine receptor regulation of circadian rhythms in beta islet cells: Implications for metabolic side effects of antipsychotic drugs – Michael McCarthy, UCSD Central Insulin Resistance: Potential mechanistic link to neuropsychiatric disorders – Lawrence Reagan, University of South Carolina |
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9:15 to 11:15 AM: Grand Ballroom 3 and 4 New molecular and circuit-level approaches for understanding the effects of chronic stress in the mammalian brain – Chair, Stephan Lammel, UC Berkley; Co-chair, Garret Stuber, University of Washington An extended amygdala circuit to drive hyperarousal – Garret Stuber, University of Washington Habenular synaptic plasticity in opiate withdrawal – Manuel Mameli, University of Lausanne Architecture of habenula circuitry underlies a distinct stress-induced depression phenotype – Stephan Lammel, UC Berkley Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced synaptogenesis – Conor Liston, Weill Cornell Medicine |
9:15 to 11:15 AM: Grand Ballroom 5 Bridging molecular genetics with population health to advance precision psychiatry, Chair, Lea Davis, Vanderbilt University Medical Center; Co-chair, Hae-Kyung Im, University of Chicago PrediXcan and beyond: methods and tools to dissect the biology of complex traits – Hae-Kyung Im, University of Chicago Using GWAS, eQTL and PrediXcan (aka TWAS) to understand complex behavioral traits in mice and rats – Abraham Palmer, UCSD Leveraging electronic health records to advance psychiatric genomics and phenomics – Lea Davis, Vanderbilt University Medical Center Investigating the causal relationships between mental and physical health outcomes using Mendelian randomization – Chia-Yen Chen, Massachusetts General Hospital |
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11:30 AM to 1:30 PM: Grand Ballroom 3 and 4 Molecular Mechanisms of Pain Regulation: Chair, Rob Gereau, Washington University in St. Louis; Co-chair, Catherine Cahill, UCLA Plasticity in endocannabinoid regulation of the descending pain pathway with persistent inflammation – Susan Ingram, Oregon Health & Science University Intersection between pain and addiction – implications for kappa opioid receptors – Catherine Cahill, UCLA Pain-induced negative affect is mediated via recruitment of the kappa opioid system in the nucleus accumbens – Jose Moron-Concepcion, Washington University in St. Louis Central amygdala circuitry orchestrating the sensory and affective components of pain and itch – Rob Gereau, Washington University in St. Louis |
11:30 AM to 1:30 PM: Grand Ballroom 5 The Application of Stem Cell Models to Validate Rare and Common Variants Contributing to Schizophrenia and Autism: Chair, Michael Talkowski, Massachusetts General Hospital; Co-chair, Alexander Urban, Stanford Transcriptional signatures of loss-of-function and reciprocal dosage of neurodevelopmental loci – Michael Talkowski, Massachusetts General Hospital Functional evaluation of the neuronal impact of patient-specific aberrant NRXN1a splicing – Erin Flaherty, Mount Sinai School of Medicine Functional interpretation of noncoding GWAS variants of schizophrenia in hiPSC model – Jubao Duan, University of Chicago Analyzing the Molecular Effects of Large Neuropsychiatric CNVs with iPSC Based Neuronal Tissue Culture Models – Alexander Urban, Stanford Transcriptional consequences of genomic variation in post-mortem schizophrenia brains – Douglas Ruderfer, Vanderbilt University |
1:30 to 7:00 PM Break
7:00 to 8:00 PM: Grand Ballroom 3 and 4
Plenary talk: Josh Gordon “Opportunities & challenges in psychiatric neuroscience”, Introduction, Carrie Bearden, UCLA