2022 Molecular Psychiatry Meeting Schedule
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7:00 AM to 9:00 AM Concurrent Session 1 Neuronal Circuit Mechanisms Underlying Complementary Facets of Social Behaviours, Chair: Manuel Mameli, The University of Lausanne Neural Representation of Group Sociality and Communication in Bats, Neural Circuit Mechanisms of Social Reward, An Habenular Circuit for Parental Behaviours, |
7:00 AM – 9:00 AM Concurrent Session 2 Poster Talks Alterations in the Expression of CircRNAs Derived from Schizophrenia GWAS Loci in iPSC-Derived Neuronal Cultures of Patients With Early Onset Schizophrenia, Defining the Global Protein Interaction Landscape of High Confidence Autism Spectrum Disorder Risk Genes, Relating Interindividual Differences in Cerebral Organoids to Longitudinal Infant Brain Growth, Inducible Calling Cards: Developing Mouse Reagents for Temporally Controlled Recording of Molecular States and Neural Activity, Investigating Microglial Remodeling of Synapses in Major Depressive Disorder-Associated Suicide Death, Mitochondrial DNA Variants Associated With Bulimia Nervosa, Modeling PTSD Differential Gene Expression in iPSC Derived Neural Cultures Treated With Glucocorticoids, Detection of Autism Spectrum Disorder-Related Pathogenic Variants by a Novel Structure-Based Approach, Searching for Schizophrenia Biology: Overlap Analysis of Cell Type-Specific Phenotypes in CNV Mouse Models, Striatal Thalamic Resting-State Network Dysconnectivity in Youth With 22q11.2 Deletion Syndrome, The Effects of Genetic Polymorphisms in Dopamine Signaling on Prefrontal Functional Connectivity and Working Memory Performance, |
9:00 AM to 9:15 AM Break
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9:15 AM to 11:15 AM Concurrent Session 1 The Case for Deep Phenotyping in Psychiatric Genetics: Insights from Rare CNVS in Neurodevelopment, Chair: Carrie Bearden, UCLA; Co-Chair: David Glahn, Harvard Medical School/Boston Children’s Hospital Rate of Deleterious Copy Number Variants Similar in Early Onset Psychosis and Autism Spectrum Disorders: Implications for Clinical Practice, Prioritizing Genes Driving Neuroanatomic Features in 22q11.2 Deletion Syndrome Using Imaging Transcriptomics, Deep Phenotyping of the Schizophrenia-Associated 3q29 Deletion Exposes the Cerebellum as a Central Point of Vulnerability, Phenotyping Across CNVs, Genes, and Exons in Autism, |
9:15 AM – 11:15 AM Concurrent Session 2 Natural Sleep Regulation and Psychiatric and Neurologic Diseases Characterized by Dysregulated Sleep: Hanna M. Ollila, Chair and Jacqueline Lane, Co-Chair A Novel Target to Modulate Wakefulness and Cognition – The Neurosteroid Approach, Martin Schalling, Karolinska Institutet Sleep Control Across Lifespan, Shibin Li, Stanford University Shared Genetic Underpinnings of Sleep and Psychiatric Disorders, Jacqueline Lane, Massachusetts General Hospital, Center for Genomic Medicine and Broad Institute for Harvard and MIT USF Transcription Factors Regulate Sleep and Circadian Rhythms, Nasa Sinnott-Armstrong, Stanford University |
11:15 AM – 11:30 AM Break
11:30 AM – 12:30 PM The Tianqiao and Chrissy Chen Plenary
Lahaina 1 and 2
A Molecular- Neural Circuitry Substrate for Cognitive Dysfunction in Schizophrenia, David Lewis, University of Pittsburgh
12:30 PM – 5:00 PM Mid-Day Break
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5:00 PM – 7:00 PM Concurrent Session 1 Emerging Intersectional Technologies for Probing Molecular Mechanisms of Neurotransmitter Co-Transmission in Brain and Behavior, Chair: Zachary Freyberg, University of Pittsburgh Intersectional Genetic Approaches to Dissecting Roles of Dopamine/Glutamate Co-Transmission in Cell Resilience, Intersectional Genetic Tools Reveal Cell-Type Specific Transcriptional Networks of Co-Transmitting Glutamatergic and Dopaminergic Neurons, INTRSECT: Precise Virus-Based Molecular Tool Expression in Multiply-Defined Neuron Subpopulations, Diverse Functions of VTA Neurons Defined by Multiple Genetic Characteristics, |
5:00 PM – 7:00 PM Concurrent Session 2 Modeling Neurodevelopmental Disorders Using Human Pluripotent Stem Cells, Chair: Sundari Chetty, Stanford University Alterations in Neuronal physiology, Development and Function Associated with a Common Duplication of Chromosome 15 Involving CHRNA7, Human Neuronal Activity-Dependent Gene Programs Enriched for Autism Heritability, Modeling Brain Overgrowth in Autism Using Human Pluripotent Stem Cells, |
7:00 AM – 9:00 AM Poster Session with Breakfast
Maui Suites 1-3
9:00 AM – 9:15 AM Break
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9:15 AM – 11:15 AM Concurrent Session 1 The Role of Astrocytes in Neurodevelopmental and Psychiatric Disorders, Chair: Zila Martinez-Lozada, The Children’s Hospital of Philadelphia BDNF Signaling onto Astrocyte TrkB.T1 Drives Astrocyte Structural Plasticity and Supports Glutamatergic Synaptogenesis, Neurons and Endothelial Cells Regulate Astrocyte Transcriptome, Role of Astrocytes in Environment-Environment interaction: Focus on Dopaminergic Neurotransmission in the Striatum, Astrocyte-Autonomous WNT/beta-Catenin Signaling Regulates Synapse Maturation and Social Behavior, |
9:15 AM – 11:15 AM Concurrent Session 2 Linking Mental Health and Physical Health Using Genetics, Functional Genomics, and Large Scale Electronic Health Record Data, Chair: Kritika Singh, Vanderbilt University Medical Center Investigating the Shared Functional Biology of Coronary Artery Disease and Depression, Investigating the Psychiatric Comorbidities of Endometriosis from Genetic and Phenotypic Perspectives, Exploring the Clinical Associations and Genetic Etiology of Adult Weight Trajectories Using Electronic Health Records, Genome-Wide Association Study of Problematic Opioid Prescription Use in 132,113 23andMe European Research Participants, |
11:15 AM – 4:00 PM Mid-Day Break
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4:00 PM – 6:00 PM Concurrent Session 1 New Technologies and Novel Insights for Dissecting Dopaminergic and Serotonergic Circuits, Chair: Stephan Lammel, UC Berkeley Dopamine Firing and Release in a Heterogenous Mesoaccumbal Dopamine System, All Optical Investigation of Synaptic Connectivity in the Intact Brain, Imaging Serotonin and Psychedelic With Genetically Encoded Indicators, Behavioral and Dopaminergic Signatures of Resilience, |
4:00 PM – 6:00 PM Concurrent Session 2 Cell-type and Context-Specific Effects of Genetic Risk Variants for Neuropsychiatric Disorders, Chair: Jason Stein, University of North Carolina at Chapel Hill Cell-Type and Context-Specific Genetic Influences on Chromatin Accessibility, Expression, and Proliferation in Human Neural Progenitor Cells and Neuronal Progeny, Brain Cell-Type Regulatory Landscapes and Associations with Disease, Revisiting the Hypothesis for Prioritizing Schizophrenia Risk Variants, In vivo Perturb-Seq: Scalable Investigation of Gene Function in the Developing Brain, |
6:00 PM – 6:15 PM Break
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6:15 PM – 8:15 PM Concurrent Session 1 iPSC-Based Platform Development for Major Psychiatric Disorder Modeling and Discovery, Chair: Kimberly Christian, University of Pennsylvania Characterization of Astrocyte-Derived Exosomes in Bipolar Disorder and Their Impact on Recipient Neurons, Using iPSCs to Investigate the Impact of Schizophrenia-Associated Risk Genes on Neuronal Activity and Synaptic Function, Modeling Plasticity of Human iPSC-Derived Neurons on Multi-Electrode Arrays, |
6:15 PM – 8:15 PM Concurrent Session 2 Establishing Brain-Behavior Relationships with Neuromodulation, Chair: Nolan Williams, Stanford University Circuit-Targeted Neuromodulation Across Symptoms and Disorders, How Will I Know if Its Working? Monitor-Markers for Therapeutic rTMS? Probing and Rescuing Dysfunctional Brain Circuits in Depression, Applying Spaced Theta Burst Stimulation to Modulate the Neural Circuitry Underlying Neuropsychiatric Illness, |
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7:00 AM – 9:00 AM Concurrent Session 1 Decoding Prefrontal Cortical Physiology: Circuits and Novel Molecular Targets in Health and Disease, Chair: Nikolaos Mellios, University of New Mexico Health Sciences Center Prefrontal Reprogramming of Sensory Cortex in Health and Disorders, Neuro Modulation of Executive Function in the PFC: A Pharmacological Approach, Glutamatergic Modulation of the Cortex: The Role of NMDAR in Learning and Flexibility, Involvement of the Cortico-Striatal Circuits in the Development of Food-Addiction, |
7:00 AM – 9:00 AM Concurrent Session 2 Leveraging the Psychiatric Disease Spectrum Towards an Improved Understanding of Brain Dysfunction, Chair: Marc Fuccillo, University of Pennsylvania Cross-CNV Single-Cell RNA Sequencing Analysis of Mouse Models to Study Overlap Between Diagnoses, Aberrant Sensory Processing in the 22q11.2 Deletion Mouse Model, Impact of Nrxn1a Mutations on Neural Circuits for Reward Processing and Motor Control, Functional Interrogation of Disease Associated Copy Number Variants Using Human Pluripotent Stem Cell Based Models, |
9:00 AM to 9:15 AM Break
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9:15 AM – 11:15 AM Concurrent Session 1 Genetic Models for Autism Spectrum Disorder, Chair: Bryan Luikart, Dartmouth Pharmacological Rescue of TCF4-Dependent Myelination Defects in a Mouse Model of ASD, Functional Analysis of ASD Risk Genes in Zebrafish Identifies Convergent Pathways, Precision Genomics in Neuropsychiatric and Neurodevelopmental Disorders Empowered by the New Era of Long-Read Sequencing, |
9:15 AM – 11:15 AM Concurrent Session 2 Microglia at the Synapse – Deciphering the Relevant Mechanisms in Schizophrenia, Chair: Martin Schalling, Karolinska Institutet From Risk to Mechanism – The Role of Glia at the Synapse in Early Schizophrenia, Maturation of Schizophrenia-Associated Circuits: Implementation of Single Cell and Spatial Omics, Ultrastructural Relationships Between Microglia and Synapses, Microglia and Sensory Modility, |
11:15 AM – 1:00 PM Lunch (on your own)
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1:00 PM – 3:00 PM Concurrent Session 1 Synapse and Circuit Mechanisms Underlying the Etiology of Neurodevelopmental Disorders, Chair: Katherine Roche, National Institutes of Health-NINDS Neuroligins and Autism: Insights From Rare Variants, Autism-Associated Cellular Mechanisms Shaping Cortical Circuit Assembly, Ectodomain Shedding by CNTNAP2 Modulates Calcium Homeostasis and Network Synchrony, NMDA Receptor Dysfunction in Mouse Models of Autism Spectrum Disorders, |
1:00 PM – 3:00 PM Concurrent Session 2 Novel Molecular Analysis of Human Postmortem Brain, Chair: Colleen McClung, University of Pittsburgh Cell-Type and Spatially Resolved Molecular Signatures in Human Brain Disorders, Epigenomic Determinants of Chromosomal Organization in Prefrontal Cortex of Subjects with Schizophrenia and Bipolar Disease, Investigating The Proteome Across Space and State in Human Postmortem Brain Tissue, Circadian and Ultradian Rhythms in Human Brain and Changes in Schizophrenia, |
3:00 PM – 4:00 PM MPA Business Meeting: Planning for the Future
Lahaina 1 and 2