2015 Molecular Psychiatry Meeting Schedule
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7:45 to 9:45 AM Concurrent Session 1 Seacliff Room A+B
Monitoring and Measuring Motivational Circuits: Chair, Tom Kash, UNC and Co-Chair, Susan Ferguson, Seattle Childrens Hospital
Amygdala Circuits in Drug Abuse, Thomas Kash, UNC
The ‘Ins’ and ‘Outs’ of the Striatum: Mapping Addiction Circuits, Susan Ferguson, Seattle Childrens Hospital
What Can Movement Circuitry Tell Us About Obesity, Lex Kravitz, NIDDK
Neural Circuits Underlying Hunger, Zack Knight, UCSF
7:45 to 9:45 AM Concurrent Session 2 Seacliff Room D
Genetic Discovery and Translational Studies in Schizophrenia: Chair, Jonathan Sebat, UCSD and Co-Chair, Lilia Iakoucheva, UCSD
Insights Into Schizophrenia From Hundreds of New Genetic Associations, Stephan Ripke, Harvard
Unearthing Novel CNVs From the PGC study of Schizophrenia, Jonathan Sebat, UCSD
Transcriptional and Protein Networks Connect Genes Implicated in Psychiatric Disorders, Lilia Iakoucheva, UCSD
Modeling Predisposition to Schizophrenia Using Stem Cells, Kristen Brennand, Icahn School of Medicine at Mount Sinai
9:45 to 10:00 AM Break
10:00 to 12:00 PM Concurrent Session 1 Seacliff Room A+B
Novel Approaches for Studying Brain Disorders: Chair, Sergiu Pasca, Stanford and Co-Chair, Ben Barres, Stanford University
At the Nano-Bio Interface: Nanoelectrodes for Improved Electrophysiology Recording, Bianxiao Cui, Stanford
Tools for Anatomical and Functional Analysis of Widely Distributed Brain Networks, Viviana Gradinaru, California Institute of Technology
What Do Astrocytes Do? Ben Barres, Stanford
Developing Cellular 3D Models of the Human Cortex, Sergiu Pasca, Stanford University
10:00 to 12:00 PM Concurrent Session 2 Seacliff Room D
Translational Imaging in Substance Use Disorders: Chair, Greg Brown, UCSD and Co-Chair, Benjamin S. McKenna, UCSD
Introduction, Greg Brown, UCSD
Cocaine is Toxic to White Matter: Diffusion Tensor Imaging, Ponnada Narayana, UT Houston
MRI Measures of Brain Connectivity in Rodents Following Acute, Binge, and Chronic Ethanol Treatment, Natalie M. Zahr, SRI International
The Impact of Methamphetamine on the Brain: Translating Cellular and Microstructural Changes with Diffusion Tensor Imaging in Mice and Humans, Benjamin S. McKenna, UCSD
Graph Theory Analysis of Ethanol Self-Administering Nonhuman Primates, Qawi K. Telesford, US Army Research Laboratory and University of Pennsylvania
12:00 to 1:30 PM Lunch (on your own)
1:30 to 2:30 PM Plenary Seacliff Room A+B
Immunobiology of Narcolepsy, Emmanuel Mignot, Stanford University. Introduction, Martin Schalling, Karolinska Institutet
2:30 to 2:45 PM Break
2:45 to 4:45 PM Concurrent Session 1 Seacliff Room A+B
Molecular-Genetic Regulatory Mechanisms: Brain Development and Plasticity: Chair, John Rubenstein, University of California, San Francisco and Co-Chair, Axel Visel, UC Berkeley
Interneuron Development, John Rubenstein, UCSF
Enhancers and the Epigenome, Axel Visel, UC Berkeley
Synaptic Homeostasis Mechanisms, Graeme Davis, UCSF
Dendrite development, Jan Yuhnung, UCSF
2:45 to 4:45 PM Concurrent Session 2 Seacliff Room D
Brain Abnormalities in Psychosis: From Risk States to Chronic Illness: Chair, Daniel Mathalon, UCSF and Co-Chair, Susanna Fryer, UCSF
Functional and Structural Imaging Biomarkers of Psychosis Risk in 22q11.2 Deletion Carriers, Carrie Bearden, UCLA
Multi-site fMRI Study of Cognitive Control-Related Brain Activation in Early Schizophrenia and Clinical High-Risk Youth, Tara Niendam, UC Davis
Resting State Brain Activity Relates to Cognition Across the Illness Span in Schizophrenia, Susanna Fryer, UCSF and SVAMC
Chronnectomics of Schizophrenia: Time-Varying Connectivity Approaches to Characterize Early Onset and Prodromal Schizophrenia, Vince D. Calhoun, Mind Research Network and University of New Mexico
4:45 to 5:45 PM Seacliff Foyer A-C
Poster Session
7:45 to 9:45 AM Concurrent Session 1 Seacliff Room A+B
Circuit Specificity of Molecular Alterations in Psychosis: Chair, David Lewis, University of Pittsburgh and Co-Chair, Ken Fish, University of Pittsburg
Dopaminergic Regulation of Dendritic Spines in the Prefrontal Cortex, Ariel Deutch, Vanderbilt
Layer-specific Alterations in Cortical Chandelier Cell Inputs to Pyramidal Neurons in Schizophrenia, Ken Fish, University of Pittsburg
Interactions Between Cortical Basket and Pyramidal Neurons: Impact on Neural Network Oscillations in Schizophrenia, David Lewis, University of Pittsburg
7:45 to 9:45 AM Concurrent Session 2 Seacliff Room D
Neurobiological Models for Psychiatric Disorders: Chair, Brady Maher, Lieber Institute and Co-Chair, Bryan Luikart, Dartmouth
A Retroviral CRISPR-Cas9 System for Phenotype Discovery of Autism Candidate Genes in Developing Neurons, Bryan Luikart, Dartmouth
Elucidating the Mechanisms of Epilepsy and Autism Using Genetically Defined Mouse and Human Models of Tuberous Sclerosis Complex, Helen Bateup, UC Berkeley
Phenotype Discovery and Therapeutic Target Identification Using a Cell Autonomous Model of Neurodevelopmental Disorders, Brady Maher, Lieber Institute
Mouse Models of Autism to Test Hypotheses About Causes, and for Preclinical Evaluation of Potential Therapeutics, Jacqueline Crawley, UC Davis
9:45 to 10:00 AM Break
10:00 to 12:00 PM Concurrent Session 1 Seacliff Room A+B
Working Towards Translational Models for Endophenotypes in Psychiatric Disorders: Chair, Andres Buonanno, NIH and Co, Chair, Julio Licinio, Co-Chair, South Australian Health and Medical Research Institute (SAHMRI) and Flinders University
Exploring High-Throughput Biomarkers for Cognitive Deficits: Oxidative Stress and Autofluorescence, Akira Sawa, Johns Hopkins
The Stress-Antidepressant-Diet (SAD) Paradigm: A New Animal Model to Study the Long-Term Metabolic Effects of Antidepressant Exposure, Julio Licinio, South Australian Health and Medical Research Institute (SAHMRI) and Flinders University
Bidirectional Neuregulin and NMDA Receptor Signaling in GABAergic Interneurons, Potential Cognitive Targets, Andres Buonanno, NIH
Translating OCD GWAS Findings into Mice to Identify Disease Mechanisms, Stephanie Dulawa, University of Chicago
10:00 to 12:00 PM Concurrent Session 2 Seacliff Room D
Functional Support for Alcohol Dependence GWAS candidates from Model Organisms: Chair, Brien Riley, Virginia Commonwealth University and Co-Chair, Michael Miles, Virginia Commonwealth University
Using C. Elegans for Validation and Discovery of Genes Involved in Acute Behavioral Responses to Alcohol, Andrew G. Davies, Virginia Commonwealth
Ras Suppressor 1 Acts Downstream of Integrin to Regulate Rac1 Activity and Ethanol Consumption in Drosophila and Humans, Adrian Rothenfluh, UT Southwestern
Genetic Analysis of Behavior and the Brain Regional Transcriptome in a Mouse Model of Progressive Ethanol Consumption, Michael Miles, Virginia Commonwealth
Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Sensitivity and Tolerance: Brien Riley, Virginia Commonwealth
12:00 to 1:30 PM Lunch (on your own)
1:30 to 2:30 PM Plenary Seacliff Room A+B
Transcriptional Dynamics of Neurodevelopmental Disorders, Danny Weinberger, Lieber Institute: Introduction, William Bunney, UCI
2:30 to 2:45 PM Break
2:45 to 4:45 PM Concurrent Session 1 Seacliff Room A+B
Big Data for Little People: Large-scale Developmental Neuroimaging Initiatives: Chair, Terry Jernigan, UCSD and Co-Chair, Jay Giedd, UCSD
Successfully Harmonized Imaging Data from Multisite Developmental Studies, Adolf Pfefferbaum, SRI Interational
Harmonizing the Connectome: Anders Dale, UCSD
Neuroimaging in Twins: Defining Age, Gene, Environment Interactions, Jay Giedd, UCSD
Addiction, Neuroimaging and Big Data, Hugh Garavan, University of Vermont
Models of Risk and Resilience: BJ Casey, Cornell
2:45 to 4:45 PM Concurrent Session 2 Seacliff Room D
Using Mouse Models to Study Circuit Mechanisms Implicated in Psychiatric Disease: Chair, Vikaas Sohal, UCSF and Co-Chair, Josh Gordon, Columbia
From Gene to Behavior: Hippocampal-Prefrontal Synchrony in the 22q11 Microdeletion Syndrome, Josh Gordon, Columbia
Cortical Dependent Network Mechanisms Underlying Stress Induced Behavioral Disorders, Kaf Dzirasa, Duke
Cortical Control of Neuromodulatory Circuits in Motivated Behavior, Melissa Warden, Cornell
Restoring Interneuron-Driven Gamma Rhythms May Rescue Cognition in Mice Which Model Aspects of Schizophrenia, Vikaas Sohal, UCSF
7:45 to 9:45 AM Concurrent Session 1 Seacliff Room A+B
Drug Addiction: from Molecules to Circuits: Chair, Kirill Martemyanov, Scripps Research Institute and Co-Chair, Christopher Cowan, Harvard
Regulating Opioid Receptor Signaling in Mesolimbic Reward Circuit: Kirill Martemyanov, Scripps Research Institute
Transcriptional and Translational Mechanisms in Cocaine-induced Plasticity, Christopher Cowan, Harvard
The Dark Side of Opioids: Limiting Tolerance and Dose Escalation, Howard B. Gutstein, MD Anderson
Dopamine Circuit Mechanisms of Individual Alcohol Drinking Behaviors, Ming-Hu Han, Icahn School of Medicine at Mount Sinai
7:45 to 9:45 AM Concurrent Session 2 Seacliff Room D
Genetics and Genomics of Affective Disorders: Chair, Eli Stahl, Icahn School of Medicine at Mount Sinai and Co-Chair, John Kelsoe, UCSD
GWAS Meta-analyses of Bipolar Disorder and Schizophrenia, Stephan Ripke, Charité Universitätsmedizin Berlin
Psychiatric Phenotypes in Large Scale Bipolar Disorder and Bipolar-Schizophrenia GWAS Meta-Analyses, Andrew McQuillin, University College London
Molecular Markers of Depression, Na Cai, Oxford
Genome-scale Transcriptional Regulatory Network Models of Neuropsychiatric Disease, Seth Ament, Institute for Systems Biology
9:45 to 10:00 AM Break
10:00 to 12:00 PM Concurrent Session 1 Seacliff Room A+B
Neural Circuit Formation Throughout The Lifespan: Chair, Anna Molofsky, UCSF and Co-Chair, Eric Ullian, UCSF
Glia Modulate the Innate Immune System to Promote Synapse Development, Anna Molofsky, UCSF
Dysregulation of Astrocyte Extracellular Signaling in Neurodevelopmental Disorders, Eric Ullian, UCSF
A Systemic Approach for Rejuvenating the Old Brain, Saul Villeda, UCSF
Imaging Experience-Dependent Synapse Pruning in Vivo, Yi Zuo, UC Santa Cruz
10:00 to 12:00 PM Concurrent Session 2 Seacliff Room D
The Origin of Developmental Risk in Psychiatric Disorders: Chair, Ron McKay, Lieber Institute and Co-Chair, Arnold Kriegstein, UCSF
Signaling Supporting Expanded Germinal Regional and Progenitor Development in Human Neocortical Development, Michael Oldham, UCSF
Mechanisms that Determine Transdifferentiation to Neurons, Marius Wernig, Stanford
A Systematic Strategy to Map the Genetic and Epigenetic Interactions that Generate the Unique Biology of Individual Humans, Josh Chenoweth, Lieber Institute
12:00 to 1:30 PM Lunch (on your own)
1:30 to 3:30 PM Concurrent Session 1 Seacliff Room A+B
Essential Pathways and Circuits of Autism Pathogenesis: Chair, Gul Dolen, Johns Hopkins and Co-Chair, Jennifer Darnell, Rockefeller
Gene Length Matters in Autism, Mark Zylka, UNC
Translational Control by FMRP, Targets and Mechanism, Jennifer Darnell, Rockefeller
Endosomal Signaling Deficits in Intellectual Disability and Autism, Chiara Manzini, George Washington
Social reward: Basic mechanisms and autism pathogenesis, Gul Dolen, Johns Hopkins
1:30 to 3:30 PM Concurrent Session 2 Seacliff Room D
New Insights into the Role of Glutamate Transporter SLC1A1 in Neuropsychiatric Disorders: Chair, Frank Middleton, SUNY and Co-Chair, Bita Moghaddam, University of Pittsburg
Opening Remarks: Glutamate and Psychosis: Setting the Stage for SLC1A1/EAAT3, Frank A. Middleton, SUNY
The Role of EAAT3 in the Action of Psychostimulants, Suzanne Underhill, NIMH
Glutamate and OCD … What is the Evidence? James Knowles, USC
Characterization of SLC1A1 CNVs in Families and Individuals with Schizophrenia, Parisa Afshari, SUNY
Discussant Perspective and Remarks, Bita Moghaddam, University of Pittsburg
3:30 to 3:45 PM Break
3:45 to 5:45 PM Concurrent Session 1 Seacliff Room A+B
Olfactory Epithelium as a Source of Surrogate Neurons for Psychiatry research: Chair, Nicola Cascella, Sheppard Pratt Hospital and Co-Chair, Koko Ishizuka, Johns Hopkins
Characterization of Olfactory Cells as Aurrogate Biospecimens to Define Brain-Relevant Molecular and Functional changes, Youjin Chung, Johns Hopkins
DISC1 Phosphorylation-Dependent Defects in Neural Fate, Corticogenesis, and Cognitive Function in Psychotic Disorders, Koko Ishizuka, Johns Hopkins
Title: Transcriptional Markers of Mood Stabilization in Patient-Derived Olfactory Neuroepithelium, Evaristus Nwulia, Howard
Extracellular Matrix Abnormalities in Major Psychoses: From the CNS to the Olfactory Mucosa and Back, Harry Pantazopoulos, Harvard
3:45 to 5:45 PM Concurrent Session 2 Seacliff Room D
Beyond DNA: what genes can tell us about neuropathology: Chair, Stephan Sanders, UCSF and Co-Chair, Jeremy Willsey UCSF
Convergent Approaches to ASD Neurobiology, Stephan Sanders, UCSF
What do Communities of Risk Genes Tell Us About the Origins of Autism? Bernie Devlin, University of Pittsburgh
The Anatomical Distribution of Genetic Risk: Joe Dougherty, Washington University