2019 Molecular Psychiatry Meeting Schedule


Download full schedule PDF here.


8:00 AM to 10:00 AM Concurrent Session 1
Garden Room

Cellular and Molecular Mechanisms of Neurodevelopmental and Psychiatric Disorders: Karun Singh, Chair, and Kristen Brennand, Co-Chair

Prioritization of Potential Therapeutic Targets by Analysis of Postmortem Human Schizophrenic Brain and Induced Pluripotent Stem Cell Models, Jennifer A. Erwin, Lieber
Institute for Brain Development

A Platform to Identify Autism-Associated Protein Interaction Networks, Karun Singh, Stem Cell and Cancer Research Institute, McMaster University

Using Stem Cells to Explore the Genetics Underlying Neuropsychiatric Disease, Kristen Brennand, Icahn School of Medicine at Mount Sinai

Hypoxia-Induced Corticogenesis Defects in a Human Cellular Model of Brain Injury of Prematurity, Anca Pasca, Stanford University


8:00 AM to 10:00 AM Concurrent Session 2
Waterfront AB

Neuronal Ectodomain Shedding and Ectodomain-Mediated Signaling: Implications for Pathogenesis, Biomarkers, and Therapies: Peter Penzes, Chair

Novel Functions of Synaptic Ectodomains Detectable in the CSF, Peter Penzes, Northwestern University

Ectodomain Shedding as a Molecular Switch to Establish Functional Synaptic Networks, Hisashi Umemori, Massachusetts General Hospital/Harvard

Myelin Plasticity in Health and Disease, Michelle Monje-Deisseroth, Stanford

10:00 AM to 10:15 AM Break


10:15 AM to 12:15 PM Concurrent Session 1
Garden Room

Molecular Models for Autism Spectrum Disorders: Bryan Luikart, Chair and Brady Maher, Co-Chair

Do Defects in Oligodendrocytes Contribute to Pathophysiology in Autism Spectrum Disorders?, Brady J. Maher, Lieber Institute for Brain Development

Investigating the Molecular Basis of Autism Using Mouse and Human Brain Organoid Models of Tuberous Sclerosis Complex, Helen Bateup, University of California, Berkeley

Fetal Immune Activation is Required for the Development of Autism-Like Behavior in Mice, Kaoru Saijo, Department of Molecular and Cell Biology, Helen Wils Neuroscience Institute, University of California, Berkeley

Studying Macrocephalic Autism Using iPSC, Carol Marchetto, Salk Institute for Biological Studies


10:15 AM to 12:15 PM Concurrent Session 2
Waterfront AB

Natural Sleep Regulation and Psychiatric and Neurologic Diseases Characterized by Dysregulated Sleep: Hanna M. Ollila, Chair and Jacqueline Lane, Co-Chair

A Novel Target to Modulate Wakefulness and Cognition – The Neurosteroid Approach, Martin Schalling, Karolinska Institutet

Sleep Control Across Lifespan, Shibin Li, Stanford University

Shared Genetic Underpinnings of Sleep and Psychiatric Disorders, Jacqueline Lane, Massachusetts General Hospital, Center for Genomic Medicine and Broad Institute for Harvard and MIT

USF Transcription Factors Regulate Sleep and Circadian Rhythms, Nasa Sinnott-Armstrong, Stanford University


12:15 PM to 2:00 PM Lunch (on your own)


2:00 PM to 3:00 PM Plenary
Garden Room

Molecular, Cellular and Circuit-Level Control of Social Behaviors: Catherine Dulac, Harvard University, Higgins Professor of Molecular and Cellular Biology


3:00 PM to 3:15 PM PM Break


3:15 PM to 5:15 PM Concurrent Session 1
Garden Room

The Role of Puberty in Brain Maturation: Relevance to Psychiatric Disease Risk: Kristen Delevich, Chair and Megan Herting, Co-Chair

Pubertal Maturation and Structurally Distinct Amygdala Subregion Development in Children and Adolescents, Megan Herting, University of Southern California

Sex-Specific Effects of Puberty on Approach-Avoidance Behavior and Dendritic Spine Pruning, Kristen Delevich, University of California, Berkeley

Sexual Differentiation of Neural Circuits of Social Anxiety, Brian Trainor, University of California, Davis

The Influence of Puberty on Neural Systems of Social Threat and Reward: Links to Anxiety and Depression Risk, Cecile Ladouceur, University of Pittsburgh


3:15 PM to 5:15 PM Concurrent Session 2
Waterfront AB

Beyond the Central Dogma: From Junk DNA to Brain Disorders: Alexandre Cristino, Chair and Hyejung Won, Co-Chair

Functional Dissection of Neural Enhancers Using Massively Parallel Reporter Assays, Fumitaka Inoue, School of Pharmacy, University of California, San Francisco

Detection on Noncoding Risk Factors for Autism Spectrum Disorder With Whole-Genome Sequencing, Stephan Sanders, School of Medicine, University of California, San Francisco

Connecting Gene Regulatory Relationships to Neurobiological Mechanisms of Brain Disorders, Hyejung Won, University of North Carolina

Unravelling the Functional Effects of Rare microRNA Mutations Identified in Schizophrenia Patients, Alexandre Cristino, Griffith Institute for Drug Discovery, Griffith


8:00 AM to 10:00 AM Concurrent Session 1
Garden Room

Synaptic Pathologies in Neurodevelopmental Disorders: Bruce Herring, Chair and Kevin Bender, Co-Chair

The Role of RhoGEF Proteins in Synaptic Transmission and Neurodevelopmental Disorders, Bruce Herring, University of Southern California

CRISPR Nanoparticle-Mediated Gene Editing in the Mouse Model of Fragile X Syndrome, Hye Young Lee, The University of Texas, Health Science Center at San Antonio

Synaptic Mechanisms of Neurodevelopmental Disorder Risk Factors ANK2 and ANK3, Peter Penzes, Northwestern University

Scn2a Dysfunction in Neurodevelopmental Disorders, Kevin Bender, University of California, San Francisco


8:00 AM to 10:00 AM Concurrent Session 2
Waterfront AB

Proteomic Technologies Applied to Neuroscience: Ruth Hüttenhain, Chair and Nevan Krogan, Co-Chair

Using Proteomic Approaches to Understand the Mechanism of Disease, Nevan Krogan, University of California, San Francisco

Proximity Labeling: Spatiotemporally-Resolved Proteomics and Transcriptomics for Neuroscience, Shui Han, Stanford

Identification of Spatiotemporally-Resolved GPCR Protein Interaction Networks Regulating Receptor Function, Ruth Hüttenhain, University of California, San Francisco

Mapping the Protein-Protein Interaction Networks of Autism Spectrum Disorder Risk Genes, Yefim Zaltsman, University of California, San Francisco


10:00 AM to 10:15 AM Break


10:15 AM to 12:15 PM Concurrent Session 1
Garden Room

Neural Circuit Basis of Adult Hippocampal Neurogenesis in Cognition and Emotion: Juan Song, Chair and Amar Sahay, Co-Chair

Dysregulation of Hippocampal Adult-Born Neurons Disrupts Brain-Wide Functional Network Associated With Memory, Juan Song, University of North Carolina, Chapel Hill

BMP Regulation of Hippocampal Neurogenesis Mediates the Behavioral Effects of Antidepressants, Jack Kessler, Northwestern University

Neurogenesis, Memory Interference and Generalization, Amar Sahay, MGH, Harvard University

Hippocampal Neurogenesis and Forgetting, Paul Frankland, SickKids, University of Toronto

The Modulatory Function of Adult Hippocampal Neurogenesis: Impact on Mood and Cognition, Rene Hen, Columbia University


10:15 AM to 12:15 PM Concurrent Session 2
Waterfront AB

Beyond GWAS – Finding Hidden Genetic Features of Neuropsychiatric Disorders: Donard Dwyer, Chair and Xiao-Hong Lu, Co-Chair

Role of Genetic Interactions in Schizophrenia Risk, Merve Kasap, Vanderbilt University

Genetic Variants Affecting Chromatin Accessibility During Human Neuronal Differentiation, Jason Stein, University of North Carolina

Novel Single-Neuron and Genome-Editing Tools to Unravel the Pathogenic Significance of Brain Somatic Mosaicism, Xiao-Hong Lu, LSU Health Shreveport

DNA Epigenetic Modifications in Drug Addiction, Jian Feng, Florida State University


12:15 PM to 2:00 PM Lunch (on your own)


2:00 PM – 4:00 PM Concurrent Session 1
Garden Room

Neurotransmitter Transporters and Neuropsychiatric Illness: David Krantz, Chair and Susan Voglmaier, Co-Chair

Different Modes of Release for Different Neurotransmitters, Robert H. Edwards, University of California, San Francisco

New Roles for VGLUT in DA Neuron Physiology and Vulnerability, Zachary Z. Freyberg, University of Pittsburgh

Model Systems for Examining Antidepressant Mechanism of Action, David E. Krantz, University of California, Los Angeles

The Ins and Outs of Amphetamine Action, Jonathan A. Javitch, Columbia University


2:00 PM to 4:00 PM Concurrent Session 2
Waterfront AB

Maternal Immune Challenge and Neuropsychiatric Disorders: Alex Nord, Chair and Melissa Bauman, Co-Chair

Maternal Immune Activation Perturbs Temporal Progression of Cerebral Cortex Development in Mouse, Alex Nord, University of California, Davis

Chronic Maternal Interleukin-17 and Autism-Related Cortical Gene Expression, Neurobiology, and Behavior, Serena Gumusoglu, University of Iowa

Modeling Gene-Immune Interactions in Altered Neurodevelopment, Theo Palmer, Stanford University

Nonhuman Primate Model of Maternal Immune Activation, Melissa Bauman, University of California, Davis


4:00 PM to 4:15 PM Break


4:15 PM – 5:30 PM
Garden Room

Poster Talks: Tracey Petryshen, Chair

Clinically Actionable Pathways Identified in Individuals With Schizophrenia by Pharmacological Enrichment of Polygenic Risk, William Reay, School of Biomedical Sciences and Pharmacy, The University of Newcastle, Australia

A Candidate Causal Variant Underlying Both Enhanced Cognitive Performance and Increased Risk of Bipolar Disorder, Susan Shen, University of California San Francisco

Association of Primate-Specific Supragranular Enriched Gene Expression With Cortical Thickness Patterns in 22q11.2 Deletion Syndrome, Gil Hoftman, Semel Institute for Neuroscience & Human Behavior at UCLA

High-Throughput Disruption of Enhancers Active During Human Corticogensis, Evan Geller, Yale University School of Medicine

Loss of Inhibitory Neurons and Perturbed Inhibition in a Syndromic ASD Mouse Model, Huei-Ying Chen, Lieber Institute for Brain Development

The Effect of Ketamine on Fronto-Striatal Circuit Mechanisms Underlying Compulsive Grooming Behavior, Gwynne Davis, Institute for Neurodegenerative Diseases UCSF

Human Induced Pluripotent Stem Cell Derived Neurons Model Circadian Rhythm Abnormalities in Bipolar Disorder, Himanshu Mishra, Department of Psychiatry and Center for Circadian Biology, University of California San Diego; Psychiatry Service, Veterans Affairs


5:30 PM – 7:30 PM Poster Session and Reception
Lower Atrium

CLICK HERE for a list of all posters.

CLICK HERE to view all the poster abstracts.

Sponsored by:


8:00 AM to 10:00 AM Concurrent Session 1
Garden Room

Pluripotent Stem Cell Models of Rare and Common Genetic Risk for Psychiatric Disorders: Ralda Nehme, Chair and Brady Maher, Co-Chair

The 22q11.2 Microdeletion: How Might it Produce Different Neuropsychiatric Phenotypes?, Ralda Nehme, Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT

Modeling Human Brain Development and Disease at Single Cell Resolution With Brain Organoids, Giorgia Quadrato, Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at USC

Modeling Schizophrenia and Its Polygenic Risk Using Induced Pluripotent Stem Cell-Derived Neurons, Daniel J. Hiler, Lieber Institute for Brain Development

Developmental Impact of Patient-Specific TCF4 Mutations on the In Vitro Cortical Circuit, Brittany A. Davis, Lieber Institute for Brain Development


8:00 AM to 10:00 AM Concurrent Session 2
Waterfront AB

Using Molecular and Neuroimaging Biomarkers to Dissect the Heterogeneity of Psychiatric Illness: Anil Malhotra, Chair and Katherine Burdick, Co-Chair

Abnormal Cytokine and Complement C4 Levels in Cerebrospinal Fluid and Plasma Samples of Patients With Schizophrenia and Healthy Volunteers, Juan Gallego, Zucker Hillside Hospital

Data-Driven Brain-Behavior Subtypes Across Disorders, Aristotle Voineskos, University of Toronto

Interaction Between Antipsychotic Exposure and Striatal Connectivity in Psychotic Relapse, José Rubio-Lorente, Zucker Hillside Hospital

Inflammatory Biomarkers of Cognitive Function in Bipolar Disorder, Katherine Burdick, Harvard University

10:00 AM to 10:15 AM Break


10:15 AM to 12:15 PM Concurrent Session 1
Garden Room

Towards Precision Psychiatry Through Genomics and Pharmacology: John Kelsoe, Chair and Alexander Charney, Co-Chair

Studying Mood Disorders Using Patient iPSC-Derived Cells In Vitro, Krishna Vadodaria, Salk Institute

Investigating the Mechanisms of Psychotropic Drugs Through Genomics, Alexander Charney, Icahn School of Medicine at Mount Sinai

Modeling Genetic Risk Variants in Schizophrenia, Carl Sellgren, Karolinska Institutet

Identifying Gene Pathways in Lithium Response Using an iPSC Model, John Kelsoe, University of California, San Diego


10:15 AM to 12:15 PM Concurrent Session 2
Waterfront AB

Circadian Rhythm Abnormalities in Bipolar Disorder: Genetic, Molecular and Behavioral Advances in Human Subjects: Michael McCarthy, Chair 

Using Stem Cell Derived Neurons to Model Circadian Rhythm Abnormalities in Bipolar Disorder, Michael McCarthy, University of California, San Diego

Molecular Rhythm Changes in Postmortem Brains From Subjects With Bipolar Disorder and Schizophrenia, Kyle Ketchesin, University of Pittsburgh

Actigraphic Analysis of Bipolar Disorder Patients Reveals Circadian Sub-Phenotypes, Robert Gonzalez, Penn State University

Association of Bipolar Disorder and Clinical Phenotypes With Genetic Variants of Circadian Genes, Suzanne Gonzalez, Penn State University


12:15 PM to 2:00 PM Lunch (on your own)


2:00 PM to 3:00 PM Plenary
Garden Room

In Search of the Engram, Mark Mayford, Department of Psychiatry, UCSD School of Medicine


3:00 PM to 3:15 PM Break


3:15 PM to 5:15 PM Concurrent Session 1
Garden Room

Excitatory-Inhibitory Dynamics From Synapses to Systems: Bridging Rodents to Humans to Examine how the Brain Responds to Perturbation in Neurodevelopmental Conditions: Grainne McAlonan, Chair

Probing Dynamics of Excitation/Inhibition Pathways in Autism Spectrum Condition – A Pharmacological Neuroimaging Approach, Andreia Carvalho Pereira, King’s College London

Using Multiple Non-Invasive Modalities to Study the Role of Altered Inhibition in Children With Autism Spectrum Disorder, Nick Puts, Johns Hopkins University

Visual Perception as a Window Into Circuit-Level Differences in the Human Autistic Brain, Caroline Robertson, Dartmouth College

Shank3 is a Critical Determinant of Homeostatic Plasticity, Vedakumar Tatavarty, Brandeis University


3:15 PM to 5:15 PM Concurrent Session 2
Waterfront AB

Childhood Neuropsychiatric Disorders: From Genes to Biology to Therapy: Stephan J. Sanders, Chair and Jeremy Willsey, Co-Chair

Whole-Exome Sequencing in Tourette Disorder Identifies New Risk Genes and Implicates Cell Polarity in Pathogenesis, Jeremy Willsey, UCSF

Genetic Variation in Autism Spectrum Disorder and Congenital Heart Disease Converges on Common Molecular Networks, Brin Rosenthal, UCSF

Intersection of Autism Spectrum Disorder Gene Orthologs and Presynaptic Homeostatic Plasticity, Özgür Genç, UCSF

Tbr1 Regulates Pathways That Converge on Synaptogenesis in Deep Cortical Layers and Links to Autism Spectrum Disorder Pathophysiology, Siavash Fazel Darbandi, UCSF

Development of a Gene Regulation Therapy to Rescue SCN2A Haploinsufficiency in Autism Spectrum Disorder, Serena Tamura, UCSF