2019 Molecular Psychiatry Meeting Schedule
Download full schedule PDF here.
8:00 AM to 10:00 AM Concurrent Session 1
Garden Room
Cellular and Molecular Mechanisms of Neurodevelopmental and Psychiatric Disorders: Karun Singh, Chair, and Kristen Brennand, Co-Chair
Prioritization of Potential Therapeutic Targets by Analysis of Postmortem Human Schizophrenic Brain and Induced Pluripotent Stem Cell Models, Jennifer A. Erwin, Lieber
Institute for Brain Development
A Platform to Identify Autism-Associated Protein Interaction Networks, Karun Singh, Stem Cell and Cancer Research Institute, McMaster University
Using Stem Cells to Explore the Genetics Underlying Neuropsychiatric Disease, Kristen Brennand, Icahn School of Medicine at Mount Sinai
Hypoxia-Induced Corticogenesis Defects in a Human Cellular Model of Brain Injury of Prematurity, Anca Pasca, Stanford University
8:00 AM to 10:00 AM Concurrent Session 2
Waterfront AB
Neuronal Ectodomain Shedding and Ectodomain-Mediated Signaling: Implications for Pathogenesis, Biomarkers, and Therapies: Peter Penzes, Chair
Novel Functions of Synaptic Ectodomains Detectable in the CSF, Peter Penzes, Northwestern University
Ectodomain Shedding as a Molecular Switch to Establish Functional Synaptic Networks, Hisashi Umemori, Massachusetts General Hospital/Harvard
Myelin Plasticity in Health and Disease, Michelle Monje-Deisseroth, Stanford
10:00 AM to 10:15 AM Break
10:15 AM to 12:15 PM Concurrent Session 1
Garden Room
Molecular Models for Autism Spectrum Disorders: Bryan Luikart, Chair and Brady Maher, Co-Chair
Do Defects in Oligodendrocytes Contribute to Pathophysiology in Autism Spectrum Disorders?, Brady J. Maher, Lieber Institute for Brain Development
Investigating the Molecular Basis of Autism Using Mouse and Human Brain Organoid Models of Tuberous Sclerosis Complex, Helen Bateup, University of California, Berkeley
Fetal Immune Activation is Required for the Development of Autism-Like Behavior in Mice, Kaoru Saijo, Department of Molecular and Cell Biology, Helen Wils Neuroscience Institute, University of California, Berkeley
Studying Macrocephalic Autism Using iPSC, Carol Marchetto, Salk Institute for Biological Studies
10:15 AM to 12:15 PM Concurrent Session 2
Waterfront AB
Natural Sleep Regulation and Psychiatric and Neurologic Diseases Characterized by Dysregulated Sleep: Hanna M. Ollila, Chair and Jacqueline Lane, Co-Chair
A Novel Target to Modulate Wakefulness and Cognition – The Neurosteroid Approach, Martin Schalling, Karolinska Institutet
Sleep Control Across Lifespan, Shibin Li, Stanford University
Shared Genetic Underpinnings of Sleep and Psychiatric Disorders, Jacqueline Lane, Massachusetts General Hospital, Center for Genomic Medicine and Broad Institute for Harvard and MIT
USF Transcription Factors Regulate Sleep and Circadian Rhythms, Nasa Sinnott-Armstrong, Stanford University
12:15 PM to 2:00 PM Lunch (on your own)
2:00 PM to 3:00 PM Plenary
Garden Room
Molecular, Cellular and Circuit-Level Control of Social Behaviors: Catherine Dulac, Harvard University, Higgins Professor of Molecular and Cellular Biology
3:00 PM to 3:15 PM PM Break
3:15 PM to 5:15 PM Concurrent Session 1
Garden Room
The Role of Puberty in Brain Maturation: Relevance to Psychiatric Disease Risk: Kristen Delevich, Chair and Megan Herting, Co-Chair
Pubertal Maturation and Structurally Distinct Amygdala Subregion Development in Children and Adolescents, Megan Herting, University of Southern California
Sex-Specific Effects of Puberty on Approach-Avoidance Behavior and Dendritic Spine Pruning, Kristen Delevich, University of California, Berkeley
Sexual Differentiation of Neural Circuits of Social Anxiety, Brian Trainor, University of California, Davis
The Influence of Puberty on Neural Systems of Social Threat and Reward: Links to Anxiety and Depression Risk, Cecile Ladouceur, University of Pittsburgh
3:15 PM to 5:15 PM Concurrent Session 2
Waterfront AB
Beyond the Central Dogma: From Junk DNA to Brain Disorders: Alexandre Cristino, Chair and Hyejung Won, Co-Chair
Functional Dissection of Neural Enhancers Using Massively Parallel Reporter Assays, Fumitaka Inoue, School of Pharmacy, University of California, San Francisco
Detection on Noncoding Risk Factors for Autism Spectrum Disorder With Whole-Genome Sequencing, Stephan Sanders, School of Medicine, University of California, San Francisco
Connecting Gene Regulatory Relationships to Neurobiological Mechanisms of Brain Disorders, Hyejung Won, University of North Carolina
Unravelling the Functional Effects of Rare microRNA Mutations Identified in Schizophrenia Patients, Alexandre Cristino, Griffith Institute for Drug Discovery, Griffith
University
8:00 AM to 10:00 AM Concurrent Session 1
Garden Room
Synaptic Pathologies in Neurodevelopmental Disorders: Bruce Herring, Chair and Kevin Bender, Co-Chair
The Role of RhoGEF Proteins in Synaptic Transmission and Neurodevelopmental Disorders, Bruce Herring, University of Southern California
CRISPR Nanoparticle-Mediated Gene Editing in the Mouse Model of Fragile X Syndrome, Hye Young Lee, The University of Texas, Health Science Center at San Antonio
Synaptic Mechanisms of Neurodevelopmental Disorder Risk Factors ANK2 and ANK3, Peter Penzes, Northwestern University
Scn2a Dysfunction in Neurodevelopmental Disorders, Kevin Bender, University of California, San Francisco
8:00 AM to 10:00 AM Concurrent Session 2
Waterfront AB
Proteomic Technologies Applied to Neuroscience: Ruth Hüttenhain, Chair and Nevan Krogan, Co-Chair
Using Proteomic Approaches to Understand the Mechanism of Disease, Nevan Krogan, University of California, San Francisco
Proximity Labeling: Spatiotemporally-Resolved Proteomics and Transcriptomics for Neuroscience, Shui Han, Stanford
Identification of Spatiotemporally-Resolved GPCR Protein Interaction Networks Regulating Receptor Function, Ruth Hüttenhain, University of California, San Francisco
Mapping the Protein-Protein Interaction Networks of Autism Spectrum Disorder Risk Genes, Yefim Zaltsman, University of California, San Francisco
10:00 AM to 10:15 AM Break
10:15 AM to 12:15 PM Concurrent Session 1
Garden Room
Neural Circuit Basis of Adult Hippocampal Neurogenesis in Cognition and Emotion: Juan Song, Chair and Amar Sahay, Co-Chair
Dysregulation of Hippocampal Adult-Born Neurons Disrupts Brain-Wide Functional Network Associated With Memory, Juan Song, University of North Carolina, Chapel Hill
BMP Regulation of Hippocampal Neurogenesis Mediates the Behavioral Effects of Antidepressants, Jack Kessler, Northwestern University
Neurogenesis, Memory Interference and Generalization, Amar Sahay, MGH, Harvard University
Hippocampal Neurogenesis and Forgetting, Paul Frankland, SickKids, University of Toronto
The Modulatory Function of Adult Hippocampal Neurogenesis: Impact on Mood and Cognition, Rene Hen, Columbia University
10:15 AM to 12:15 PM Concurrent Session 2
Waterfront AB
Beyond GWAS – Finding Hidden Genetic Features of Neuropsychiatric Disorders: Donard Dwyer, Chair and Xiao-Hong Lu, Co-Chair
Role of Genetic Interactions in Schizophrenia Risk, Merve Kasap, Vanderbilt University
Genetic Variants Affecting Chromatin Accessibility During Human Neuronal Differentiation, Jason Stein, University of North Carolina
Novel Single-Neuron and Genome-Editing Tools to Unravel the Pathogenic Significance of Brain Somatic Mosaicism, Xiao-Hong Lu, LSU Health Shreveport
DNA Epigenetic Modifications in Drug Addiction, Jian Feng, Florida State University
12:15 PM to 2:00 PM Lunch (on your own)
2:00 PM – 4:00 PM Concurrent Session 1
Garden Room
Neurotransmitter Transporters and Neuropsychiatric Illness: David Krantz, Chair and Susan Voglmaier, Co-Chair
Different Modes of Release for Different Neurotransmitters, Robert H. Edwards, University of California, San Francisco
New Roles for VGLUT in DA Neuron Physiology and Vulnerability, Zachary Z. Freyberg, University of Pittsburgh
Model Systems for Examining Antidepressant Mechanism of Action, David E. Krantz, University of California, Los Angeles
The Ins and Outs of Amphetamine Action, Jonathan A. Javitch, Columbia University
2:00 PM to 4:00 PM Concurrent Session 2
Waterfront AB
Maternal Immune Challenge and Neuropsychiatric Disorders: Alex Nord, Chair and Melissa Bauman, Co-Chair
Maternal Immune Activation Perturbs Temporal Progression of Cerebral Cortex Development in Mouse, Alex Nord, University of California, Davis
Chronic Maternal Interleukin-17 and Autism-Related Cortical Gene Expression, Neurobiology, and Behavior, Serena Gumusoglu, University of Iowa
Modeling Gene-Immune Interactions in Altered Neurodevelopment, Theo Palmer, Stanford University
Nonhuman Primate Model of Maternal Immune Activation, Melissa Bauman, University of California, Davis
4:00 PM to 4:15 PM Break
4:15 PM – 5:30 PM
Garden Room
Poster Talks: Tracey Petryshen, Chair
Clinically Actionable Pathways Identified in Individuals With Schizophrenia by Pharmacological Enrichment of Polygenic Risk, William Reay, School of Biomedical Sciences and Pharmacy, The University of Newcastle, Australia
A Candidate Causal Variant Underlying Both Enhanced Cognitive Performance and Increased Risk of Bipolar Disorder, Susan Shen, University of California San Francisco
Association of Primate-Specific Supragranular Enriched Gene Expression With Cortical Thickness Patterns in 22q11.2 Deletion Syndrome, Gil Hoftman, Semel Institute for Neuroscience & Human Behavior at UCLA
High-Throughput Disruption of Enhancers Active During Human Corticogensis, Evan Geller, Yale University School of Medicine
Loss of Inhibitory Neurons and Perturbed Inhibition in a Syndromic ASD Mouse Model, Huei-Ying Chen, Lieber Institute for Brain Development
The Effect of Ketamine on Fronto-Striatal Circuit Mechanisms Underlying Compulsive Grooming Behavior, Gwynne Davis, Institute for Neurodegenerative Diseases UCSF
Human Induced Pluripotent Stem Cell Derived Neurons Model Circadian Rhythm Abnormalities in Bipolar Disorder, Himanshu Mishra, Department of Psychiatry and Center for Circadian Biology, University of California San Diego; Psychiatry Service, Veterans Affairs
5:30 PM – 7:30 PM Poster Session and Reception
Lower Atrium
CLICK HERE for a list of all posters.
CLICK HERE to view all the poster abstracts.
Sponsored by:
8:00 AM to 10:00 AM Concurrent Session 1
Garden Room
Pluripotent Stem Cell Models of Rare and Common Genetic Risk for Psychiatric Disorders: Ralda Nehme, Chair and Brady Maher, Co-Chair
The 22q11.2 Microdeletion: How Might it Produce Different Neuropsychiatric Phenotypes?, Ralda Nehme, Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT
Modeling Human Brain Development and Disease at Single Cell Resolution With Brain Organoids, Giorgia Quadrato, Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at USC
Modeling Schizophrenia and Its Polygenic Risk Using Induced Pluripotent Stem Cell-Derived Neurons, Daniel J. Hiler, Lieber Institute for Brain Development
Developmental Impact of Patient-Specific TCF4 Mutations on the In Vitro Cortical Circuit, Brittany A. Davis, Lieber Institute for Brain Development
8:00 AM to 10:00 AM Concurrent Session 2
Waterfront AB
Using Molecular and Neuroimaging Biomarkers to Dissect the Heterogeneity of Psychiatric Illness: Anil Malhotra, Chair and Katherine Burdick, Co-Chair
Abnormal Cytokine and Complement C4 Levels in Cerebrospinal Fluid and Plasma Samples of Patients With Schizophrenia and Healthy Volunteers, Juan Gallego, Zucker Hillside Hospital
Data-Driven Brain-Behavior Subtypes Across Disorders, Aristotle Voineskos, University of Toronto
Interaction Between Antipsychotic Exposure and Striatal Connectivity in Psychotic Relapse, José Rubio-Lorente, Zucker Hillside Hospital
Inflammatory Biomarkers of Cognitive Function in Bipolar Disorder, Katherine Burdick, Harvard University
10:00 AM to 10:15 AM Break
10:15 AM to 12:15 PM Concurrent Session 1
Garden Room
Towards Precision Psychiatry Through Genomics and Pharmacology: John Kelsoe, Chair and Alexander Charney, Co-Chair
Studying Mood Disorders Using Patient iPSC-Derived Cells In Vitro, Krishna Vadodaria, Salk Institute
Investigating the Mechanisms of Psychotropic Drugs Through Genomics, Alexander Charney, Icahn School of Medicine at Mount Sinai
Modeling Genetic Risk Variants in Schizophrenia, Carl Sellgren, Karolinska Institutet
Identifying Gene Pathways in Lithium Response Using an iPSC Model, John Kelsoe, University of California, San Diego
10:15 AM to 12:15 PM Concurrent Session 2
Waterfront AB
Circadian Rhythm Abnormalities in Bipolar Disorder: Genetic, Molecular and Behavioral Advances in Human Subjects: Michael McCarthy, Chair
Using Stem Cell Derived Neurons to Model Circadian Rhythm Abnormalities in Bipolar Disorder, Michael McCarthy, University of California, San Diego
Molecular Rhythm Changes in Postmortem Brains From Subjects With Bipolar Disorder and Schizophrenia, Kyle Ketchesin, University of Pittsburgh
Actigraphic Analysis of Bipolar Disorder Patients Reveals Circadian Sub-Phenotypes, Robert Gonzalez, Penn State University
Association of Bipolar Disorder and Clinical Phenotypes With Genetic Variants of Circadian Genes, Suzanne Gonzalez, Penn State University
12:15 PM to 2:00 PM Lunch (on your own)
2:00 PM to 3:00 PM Plenary
Garden Room
In Search of the Engram, Mark Mayford, Department of Psychiatry, UCSD School of Medicine
3:00 PM to 3:15 PM Break
3:15 PM to 5:15 PM Concurrent Session 1
Garden Room
Excitatory-Inhibitory Dynamics From Synapses to Systems: Bridging Rodents to Humans to Examine how the Brain Responds to Perturbation in Neurodevelopmental Conditions: Grainne McAlonan, Chair
Probing Dynamics of Excitation/Inhibition Pathways in Autism Spectrum Condition – A Pharmacological Neuroimaging Approach, Andreia Carvalho Pereira, King’s College London
Using Multiple Non-Invasive Modalities to Study the Role of Altered Inhibition in Children With Autism Spectrum Disorder, Nick Puts, Johns Hopkins University
Visual Perception as a Window Into Circuit-Level Differences in the Human Autistic Brain, Caroline Robertson, Dartmouth College
Shank3 is a Critical Determinant of Homeostatic Plasticity, Vedakumar Tatavarty, Brandeis University
3:15 PM to 5:15 PM Concurrent Session 2
Waterfront AB
Childhood Neuropsychiatric Disorders: From Genes to Biology to Therapy: Stephan J. Sanders, Chair and Jeremy Willsey, Co-Chair
Whole-Exome Sequencing in Tourette Disorder Identifies New Risk Genes and Implicates Cell Polarity in Pathogenesis, Jeremy Willsey, UCSF
Genetic Variation in Autism Spectrum Disorder and Congenital Heart Disease Converges on Common Molecular Networks, Brin Rosenthal, UCSF
Intersection of Autism Spectrum Disorder Gene Orthologs and Presynaptic Homeostatic Plasticity, Özgür Genç, UCSF
Tbr1 Regulates Pathways That Converge on Synaptogenesis in Deep Cortical Layers and Links to Autism Spectrum Disorder Pathophysiology, Siavash Fazel Darbandi, UCSF
Development of a Gene Regulation Therapy to Rescue SCN2A Haploinsufficiency in Autism Spectrum Disorder, Serena Tamura, UCSF